EU-funded researchers have discovered that parts of the genetic machinery controlling programmed cell death are the same in plants and animals. The findings, published in the journal Nature Cell Biology, suggest that programmed cell death arose before the evolutionary paths of plants and animals split around 1 billion years ago.
The findings are important because when programmed cell death (which is also known as ‘apoptosis’) goes wrong, the results can be disastrous. For example, when cells fail to activate the cell death programme correctly, they can multiply and form cancerous tumours. On the other hand, some neurological disorders, such as Parkinson’s disease, arise when too many cells die.
Plants also regulate when their cells die, but until now, researchers thought that the processes controlling apoptosis were completely different in plants and animals.
In this study, scientists from Spain, Finland, Sweden and the UK studied a protein called Tudor staphylococcal nuclease (TSN) in mice, humans, the Norway spruce and mouse-ear cress. Their investigations reveal for the first time that the destruction of TSN is an important part of the programmed cell death mechanism in both plants and animals.
During programmed cell death in animals, TSN is broken down by proteins called caspases. Plants do not have caspases, but they do have similar proteins called metacaspases, which are also known to be involved in apoptosis. The researchers found that in plants, TSN is broken down by metacaspases.
The team also found that TSN is vital for the development of embryos and pollen in the mouse-ear cress; this suggests that TSN plays an important role in preventing programmed cell death from taking place in cells that need to remain alive.
‘Our results […] demonstrate that despite the divergence of plants and animals from a common ancestor about one billion years ago and their use of distinct PCD [programmed cell death] pathways, both have retained a common mechanism to compromise cell viability through the cleavage of the same substrate, TSN,’ the researchers conclude.
EU support for the research came from projects funded under both the Sixth and Seventh Framework Programmes (FP6 and FP7 respectively).
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Category: Project results
Data Source Provider: Swedish Research Council; Nature Cell Biology
Document Reference: Sundström, J. F. et al. (2009) Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. Nature Cell Biology (in press), published online 11 October. DOI: 10.1038/ncb1979.
Subject Index: Coordination, Cooperation; Life Sciences; Medicine, Health; Scientific Research